By J. Pruitt
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High doses of AChEI can lead to a cholinergic crisis characterized by even greater muscular weakness accompanied by increased bronchial secretion, diarrhea, abdominal pain, hypersalivation and bradycardia (Juel 2007; Thanvi 2004; Garcia-Carrasco 2007). 1 Pyridostigmine Pyridostigmine (Mestinon®, Regonol®, Fig. 2; Urban 1951) Pyridostigmine bromide is the most globally used AChEI in the MG treatment. It is generally better tolerated than neostigmine bromide and has fewer gastrointestinal side effects (Juel 2005).
1992). Treatment of acquired autoimmune myasthenia gravis: a topic review. 3, pp. 360-375, ISSN 0317-1671 Vincenti, F. (2001). S. multicenter, randomized, komparative trial. 1-2, pp. S. (1993) Potentiation of glucocorticoid receptormediated gene expression by the immunophilin ligands FK506 and rapamycin. 9, pp. B. (2007) Rheumatoid artritis treatment and monitoring of outcomes – Where are we in 2007? Controversies and opportunities. 4, pp. S. (1987). Selective effects of cyclophosphamide therapy on activation, proliferation, and differentiation of human B-cells.
This isoform of AChE differs from principal synaptic isoform (AChE-S) in the structure of the Cterminal sequence (Grisaru 1999) and unlike AChE-S it forms soluble monomer, which is not anchored in the postsynaptic membrane (Seidman 1995). These structural differences make AChE-R also more sensitive to hEN101 treatment even though it binds to coding sequence of common to all isoforms. hEN101 is a 20-mer oligonucleotide active both orally and intravenously (Brenner 2003). 5´-CTGCCACGTTCTCCTGCACC-3´ hEN101 Fig.
A Look Into Myasthenia Gravis by J. Pruitt