By Collin, Catherine
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Extra resources for Advances in neuroregulation and neuroprotection
However, there are several treatments available to alleviate symptoms of the disease, such as pharmacological therapy (Korczyn et al, 2002) and surgical interference (Playfer, 1997; Gullingham, 2000). The most successful candidate for drug therapy is still L-dopa that is a precursor in DA biosynthesis. The introduction of L-dopa was revolutionary in that it became an excellent treatment in an earlier essentially untreatable disorder. Mortality has been nearly normalized and L-dopa is still considered the most effective agent for treatment of PD.
IB) used in this in vitro study. One observes that the melatonin stimulated the macrophages' capacity to ingest antigens independently of the origin of the macrophages. The maximum stimulation was for basal animal macrophages incubated with the higher melatonin concentration. Corticosterone, however, only led to an increased PI when the phagocytes were from stressed animals and had been incubated with the higher corticosterone concentration. Were the variations in the macrophages' capacity to phagocytose inert particles due to an increase in the number of cells capable of phagocytosis (measured by the Phagocytic Percentage, PP), or to the cells being more active in ingesting the antigen (measured by the Phagocytosis Efficiency, PE)?
E. (1991). Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzehamier's disease, Proc. Natl. Acad. Sci. (USA) 88, 1054010543. Stollhoff, K. and Schulte, F. J. (1987). Vitamin B12 and brain development, Eur. J. Paediatr. 146, 201-205. Tatton, W. , et al. (2003). Apoptosis in Parkinson's disease: Signal for neuronal degradation, Ann. Neurol. 53 (Suppl. 3), S61-S72. , Rajput, A. , et al (1990). Age, environments and the number of substancia nigra neurons, Adv. Neurol. 53, 201-206.
Advances in neuroregulation and neuroprotection by Collin, Catherine